Биотехнологии в медицине список научных статей
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IDENTIFICATION OF PROGNOSTICALLY SIGNIFICANT DNA METHYLATION SIGNATURES IN PATIENTS WITH VARIOUS BREAST CANCER TYPES
Breast cancer (BC) is the most frequently diagnosed cancer and one of the major causes of female mortality. The development of prognostic models based on multiomics data is the main goal of precision oncology. Aberrant DNA methylation in BC is a diagnostic marker of carcinogenesis. Despite the...
2022 / Kalinkin A.I., Sigin V.O., Nemtsova M.V., Strelnikov V.V.
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KNOCKOUT OF MUTANT ТР53 IN THE HACAT CELLS ENHANCES THEIR MIGRATION ACTIVITY
The HaCaT cell line represents the spontaneously immortalized non-carcinogenic human keratinocytes that are used as a model for studying the function of normal human keratinocytes. There are two TP53 alleles in the HaCaT cell genome, which comprise two gain-of-function (GOF) mutations acquired...
2022 / Kozhin P.M., Romashin D.D., Rusanov A.I., Luzgina Ng -
DEVELOPMENT AND CHARACTERIZATION OF A VECTOR SYSTEM BASED ON THE SIMIAN ADENOVIRUS TYPE 25
Technological versatility and the humoral and cellular immune response induction capacity have conditioned wide spread of adenoviral vectors as vaccine and gene therapy drugs. However, vaccination with Sputnik V made a significant portion of the population immune to the types 5 and 26 (Ad5 and...
2023 / Mozharovskaya T.A., Popova O., Zubkova O.V., Vavilova I.V., Pochtovyi A.A., Shcherbakov D.V., Gushchin V.A., Logunov D.Yu., Gintsburg A.L. -
SURVIVAL OF HUMAN CELLS IN TISSUE-ENGINEERED CONSTRUCTS STORED AT ROOM TEMPERATURE
Tissue-engineered constructs (TECs), the dermal equivalent (DE) and the skin equivalent (SE), are allogenic equivalents of the skin and derm used to treat critical skin loss. Selection of storage conditions that contribute to longer shelf life, thereby expanding the possibilities of logistics and...
2023 / Rogovaya O.S., Alpeeva E.V., Ruchko E.S., Eremeev A.V., Vorotelyak E.A. -
ASSESSMENT OF THE ZONA PELLUCIDA MICRODISSECTION ON ITS THICKNESS IN MAMMALIAN EMBRYOS
The zona pellucida (ZP) is a dynamically changing object that plays an important role during the preimplantation stage of embryogenesis. The ZP thickness may affect the implantation success and pregnancy rate, it is considered as a prognostic factor in a number of studies. The study was aimed to...
2023 / Sitnikov D.S., Ilia I.V., Filatov M.A., Silaeva Yu.Yu. -
COMPARISON OF THE ONCOLYTIC ACTIVITY OF RECOMBINANT VACCINIA VIRUS STRAINS LIVP-RFP AND MVA-RFP AGAINST SOLID TUMORS
Among oncolytic viruses, modified vaccinia virus Ankara (MVA), a highly attenuated vaccinia virus (VV) is a well-studied variant with promising results in preclinical and clinical trials. The Lister VV strain from the Moscow Institute of Viral Preparations (LIVP) has been studied to a lesser extent ...
2023 / Shakiba Y., Naberezhnaya E.R., Kochetkov D.V., Yusubalieva G.M., Vorobyev P.O., Chumakov P.M., Baklaushev V.P., Lipatova A.V. -
DETECTION OF SMN1 LOSS WITH PCR-BASED SCREENING TEST
Spinal muscular atrophy (SMA) is an inherited neuromuscular disease characterized by progressive skeletal muscular weakness and atrophy. The newborn screening for spinal muscular atrophy should define all molecular forms of SMA. The aim of this study is to compare a PCR-based test for detection of...
2023 / Nazarov V.D., Cherebillo C.C., Lapin S.V., Sidorenko D.V., Devyatkina Y.A., Musonova A.C., Petrova T.V., Nikiforov A.I., Ivanova A.V. -
ACTIVATION OF MICROGLIA IN THE BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS
Arterial hypertension is one of the most significant medical and social problems, being widespread and associated with the risk of renal failure, cardiovascular and cerebrovascular complications. The aim was to investigate the morphofunctional state of microglia in different regions of the rat...
2023 / Guselnikova V.V., Reznikov V.A., Sufieva D.A., Korzhevskii D.E. -
ASSESSMENT OF METASTATIC TRAITS OF THE CELLS WITH HYBRID PHENOTYPE IN BREAST CANCER
Nowadays, great attention is paid to the study of circulating tumor cells (CTCs) due to their key role in distant metastasis. At the same time there is little data on the properties of circulating cells showing simultaneous expression of the leukocyte and epithelial markers and their possible role...
2023 / Mukhamedzhanov R.K., Grigoryeva E.S., Tashyreva L.A., Perelmuter V.M., Zavyalova M.V., Savelieva O.E. -
NONINVASIVE PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY
To date the world community is actively working to optimize the approaches to determining chromosomal abnormalities in embryos. The study was aimed to assess the possibility of using noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) through analysis of cell-free DNA in spent...
2023 / Lisitsyna O.I., Ekimov A.N., Atapina E.E., Syrkasheva A.G., Goryainova E.G., Makarova N.P., Trofimov D.Yu., Dolgushina N.V. -
ATOH1 FACTOR EXPRESSION INDUCES RAPID DIFFERENTIATION OF IPSCS INTO NEURONS
The study of human induced pluripotent stem cells (iPSCs) and developing the technology for their practical use is one of the most knowledge-intensive areas of modern biomedical research. Despite the potential of using iPSCs in personalized medicine and to build cell-based models for disorders of...
2023 / Stepanov A.I., Putlyaev L.V., Dudych D.A., Galiakberova A.A., Gurskaya N.G., Lukyanov K.A. -
THE EFFECTIVENESS OF UPFLOW SLUDGE BLANKET FILTRATION (USBF) TECHNOLOGY FOR DOMESTIC WASTEWATER TREATMENT IN HANOI, VIETNAM
In this study, Upflow Sludge Blanket Filtration (USBF) technology was applied for domestic wastewater treatment in Hanoi, Vietnam. The system was continuously operated for 31 days with HRT 10 h. Before operating the system, the aerobic and anaerobic activated sludge was prepared using the real...
2023 / Nguyen Hoang Nam, Nguyen Thi Ha, Dung Nguyen Hoang, Dang Phuc Truong -
PROGNOSTIC BIOMARKERS IN THE MANAGEMENT OF SICKLE CELL DISORDER PATIENTS OF ODISHA
The predictive and diagnostic information about the patient’s health condition is provided by routinely monitoring the haematological and biochemical parameters. The current study focused at how hematobiochemical parameters affected the pathophysiology of sickle cell disease (SCD) patients....
2023 / Somali Das, Bisnu Prasad DashScopusВАК -
Жизнеспособность ядросодержащих клеток в лейкоконцентратах на этапах их получения, замораживания и декриоконсервирования
Цель – оценить жизнеспособность ядросодержащих клеток (ЯСК) в лейкоконцентратах (ЛК) на этапах их получения, замораживания и декриоконсервирования. Материалы и методы. Материал исследования – 44 ЛК доноров аллогенных гемопоэтических стволовых клеток (ГСК) и 189 аутологичных ЛК онкогематологических...
2023 / Исаева Наталья Васильевна, Минаева Наталья Викторовна, Утемов Сергей Вячеславович, Шерстнев Филипп Сергеевич, Зорина Наталья Александровна, Змеева Юлия Сергеевна, Бутолина Мария АлександровнаScopusВАКESCI -
Стволовые свойства опухолевых клеток асцитической жидкости у больных раком яичника: ключ к управлению распространением процесса
Рак яичника принято рассматривать как наиболее злокачественную и агрессивную опухоль женской репродуктивной системы, что во многом связано с ранним развитием злокачественного асцита и перитонеального канцероматоза. Опухолевые клетки, представляющие первичный очаг, а также содержащиеся в составе...
2023 / Ковалев Олег Игоревич, Вторушин Сергей Владимирович, Кайгородова Евгения ВикторовнаScopusВАКESCI -
МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ РЕГЕНЕРАЦИИ КОСТНОГО ДЕФЕКТА ПРИ ПРИМЕНЕНИИ КОСТНОГО АЛЛОГРАФТА В СОЧЕТАНИИ С АУТОПЛАЗМОЙ, ОБОГАЩЁННОЙ ТРОМБОЦИТАМИ
Плазма, обогощенная тромбоцитами, широко используется для регенерации костной ткани, так как факторы роста, высвобождаемые из активированных тромбоцитов, оказывают остеоиндуктивное действие на костные клетки. Хотя большинство доклинических и клинических исследований показывают, что концентраты...
2022 / Ташметов Эльярбек Розматжанович, Тулеубаев Берик Еркебуланович, Сагинова Дина Азимовна, Кошанова Амина Амантаевна -
HAEMATOLOGICAL PROFILE OF FARMED CLARIAS BATRACHUS WITH REFERENCE TO LENGTH AND WEIGHT FROM MULTAN, PAKISTAN
Present study was conducted to elaborate different haematological parameters of Clarias batrachus with reference to its total body length and total body weight (wet and dry). The studied haematological parameters include WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, LYM, RDW and MPV. These all...
2023 / Muhammad Farhan Nasir, Muhammad Naeem, Kashif Ali, Danish Riaz, Asma Ashraf, Amina Ayub, Majeeda Rasheed, Jannat ShafiScopusВАК -
ОБОСНОВАНИЕ ВЫБОРА МЕТОДИКИ ФУНКЦИОНАЛЬНОЙ ОЦЕНКИ РЕГЕНЕРАЦИИ НЕРВА ПРИ ЗАМЕЩЕНИИ ДЕФЕКТА БИОСИНТЕТИЧЕСКИМ АНАЛОГОМ
Были проанализированы существующие методы функциональной оценки регенерации нервов для выбора подходящего метода при замещении дефекта биосинтетическим аналогом. Поиск литературных источников осуществлен в базах данных eLIBRARY и PubMed с выбором зарубежных статей, опубликованных за последние 10...
2023 / Покровский Владимир Михайлович, Арделян Александр Николаевич, Арутюнян Нанар Армоевна, Ташу Бэла Султанмуратовна, Щербаков Олег Ярославович, Пилипенко Станислав СергеевичScopusВАКRSCI -
Pempek Fishcake from Channa micropeltes with Pumpkin Puree: Quality Assessment
Pempek is an authentic traditional dish of Indonesian cuisine. As a popular food, it needs to be both tasty and nutritious. Mashed pumpkin can add some health-beneficial properties to the traditional pempek and reduce its carbohydrate content. This research featured pempek made of farmed toman fish ...
2023 / Rabiatul Adawyah, Tri Dekayanti, Ainun Aslamiah, Muhammad Wahyu, Findya PuspitasariВАКAGRIS -
НОВАЯ ЛИОПРОТЕКТОРНАЯ СРЕДА ДЛЯ ЛИОФИЛИЗАЦИИ НЕСИМБИОТИЧЕСКИХ АЗОТФИКСИРУЮЩИХ БАКТЕРИЙ, ПЕРСПЕКТИВНЫХ ДЛЯ ПРОИЗВОДСТВА БИОУДОБРЕНИЙ
Цель исследования – разработка защитной среды для лиофилизации штамма несимбиотических азотфиксирующих бактерий, выделенного авторами из сельскохозяйственных почв Красноярского края и идентифицированного как Azotobacter sp. Штамм инкубировали на модифицированной питательной среде Сабуро при 25 °С в ...
2022 / Софья Владимировна Овсянкина, Сергей Витальевич Хижняк, Полина Александровна Аболенцева, Яна Викторовна Смольникова, Елена Николаевна Олейникова
