Биотехнологии в медицине список научных статей
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Biomineralization of Human Genomic DNA into ZIF-8, a Zeolite-Like Metal-Organic Framework
The aim of the study was to assess the capabilities of human genomic DNA biomineralization into ZIF-8 metal-organic framework (MOF) preserving DNA sequence integrity after the encapsulation cycle and composite dissolving. The study is an initial stage of the project aimed at developing an abiotic...
2024 / Shaykhutdinov I.H., Iliasov P.V., Limareva L.V., Sustretov A.S., Kokorev D.A., Sokolov A.V.ScopusВАКESCI
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Neurogenetics of Brain Connectivity: Current Approaches to the Study (Review)
Owing to the advances of neuroimaging techniques, a number of functional brain networks associated both with specific functions and the state of relative inactivity has been distinguished. A sufficient bulk of information has been accumulated on changes in connectivity (links between brain regions) ...
2024 / Proshina E.A., Deynekina T.S., Martynova O.V.ScopusВАКESCI -
Development and Synthesis of Bombesin-Based Radiopharmaceutical Precursors Modified with Knottin
Bombesin receptors on the cell surface are of great interest as a target for targeted cancer therapy. One of the strategies of targeting bombesin receptors involves the use of tropic short peptides. However, the main limitation for the wide application of peptides as drugs is their low stability in ...
2024 / Beloborodov Е. А., Iurova E.V., Fomin А. N., Saenko Yu.V.ScopusВАКESCI -
Anti-adhesive Properties of Epoxy-Treated Xenopericardium Modified with Polyvinyl Alcohol: in vitro Study of Leukocyte Adhesion in the Pulsatile Flow Model
The aim of the study is to assess protective capabilities of the polymer coating made of polyvinyl alcohol to prevent leukocyte adhesion to epoxy-treated bovine pericardium, which is used in production of bioprosthetic heart valves. Materials and Methods. Fragments of unmodified (control) and...
2024 / Ovcharenko Е. А., Glushkova T.V., Shishkova D.K., Rezvova M.A., Velikanova E.A., Klyshnikov K.Yu., Akentyeva T.N., Kostyunin A.E.ScopusВАКESCI -
Technology of Combined Identification of Macrophages and Collagen Fibers in Liver Samples
The importance of identifying pathological changes in the liver both in fundamental researches and in diagnostic practice dictates the necessity to have a convenient method of assessing functional condition of resident macrophages and connective tissue fibers. The aim of the study is to assess the...
2024 / Nikitina I.A., Razenkova V.A., Fedorova E.A., Kirik O.V., Korzhevskii D.E.ScopusВАКESCI -
Nanoparticles for Creating a Strategy to Stimulate Liver Regeneration
Presently, there is a need in the developing new approaches to stimulate liver regeneration, which would make its recovery more effective after resection. Application of nanoparticles, loaded with small bioactive molecules, with their targeted delivery into the liver is a promising approach. The...
2024 / Rodimova S.A., Kozlov D.S., Krylov D.P., Mikhailova L.V., Kozlova V.A., Gavrina A.I., Mozherov А. М., Elagin V.V., Kuznetsova D.S.ScopusВАКESCI -
Detection of Major Mutations in CFTR, SERPINA1, HFE Genes in Benign Unconjugated Hyperbilirubinemia Phenotype
The aim of the study was to search for the associations of benign unconjugated hyperbilirubinemia phenotype with rs1799945 (H63D), rs1800562 (C282Y), rs1800730 (S65C) mutations of HFE gene, rs113993960 (ΔF508) of CFTR gene, rs28929474 (PIZ), rs17580 (PIS) mutations of SERPINA1 gene. Material and...
2024 / Ivanova А. А., Apartseva N.E., Kashirina A.P., Nemtsova E.G., Ivanova Y.V., Kruchinina M.V., Kurilovich S.A., Maksimov V.N.ScopusВАКESCI -
Cell Model for Testing Pharmaceuticals Targeting Human PD-L1
The aim of this study was to create and evaluate a cell model designed for in vitro and in vivo testing of anti-human PD-L1 therapeutic and diagnostic agents’ specificity. Materials and Methods. Genetically modified cells expressing human PD-L1 (strain CT26-PD-L1) were obtained by retroviral...
2024 / Shashkova O.A., Terekhina L.A., Malakhov I.S., Pinevich A.A., Vartanyan N.L., Avrov K.O., Krutetskaya I.Yu., Gryazeva I.V., Berlina M.A., Stolbovaya A.Yu., Smirnov I.V., Fedorenko S.V., Krylova A.A., Nadporojskii M.A., Shatik S.V., Stanzhevskii A.A., Samoilovich M.P.ScopusВАКESCI -
Composite Tissue-Engineered Small-Diameter Vascular Grafts Based on Polycaprolactone and Polyurethane with Growth Factors and Atrombogenic Drug Coatings: Surface Ultrastructure, Physical and Mechanical Properties
There is a growing need for synthetic small-diameter vascular grafts (<6 mm) for bypass surgery since the majority of currently developed products have demonstrated unacceptable high frequency of thrombosis in preclinical studies. The proprietary composite vascular graft based on a nonwoven polymer ...
2024 / Senokosova E.A., Prokudina Е. S., Krivkina Е. О., Glushkova T.V., Velikanova Е. А., Khanova M.Yu., Torgunakova Е. А., Matveeva V.G., Antonova L.V.ScopusВАКESCI -
Efficacy of Poly-3-Hydroxybutyrate Enriched with Simvastatin in Bone Regeneration after Tooth Extraction (Experimental Study)
Physiological resorption of bone tissue after tooth extraction leads to a decrease in the volume of bone tissue available for implantation and makes it difficult to install dental implants. Preservation of the well after tooth extraction is the solution to this problem, with the choice of bone...
2024 / Salekh K.M., Muraev A.A., Dolgalev A.A., Dymnikov A.B., Bonartseva G.A., Makhina T.K., Chesnokova D.V., Voinova V.V., Bonartsev A.P., Mokrenko M.E., Ivanov S.Y.ScopusВАКESCI -
Application of Hydroxyapatite Obtained by Different Techniques: Metabolism and Microarchitecture Characteristics (Review)
The literature reports on microarchitecture and metabolism characteristics of synthetic hydroxyapatite obtained by different techniques were analyzed. The direct relation between hydroxyapatite production process and its microarchitecture was stated to exist. In turn, hydroxyapatite...
2024 / Markelov V.A., Danilko K.V., Solntsev V.A., Pyatnitskaya S.V., Bilyalov A.R.ScopusВАКESCI -
Возможности использования наночастиц для улучшения эффективности и безопасности фармакотерапии во время беременности
Актуальность. Фармакотерапия во время беременности сопряжена с большими рисками для плода в случае терапии экстрагенитальной патологии матери, кроме того, приоритетными остаются и вопросы улучшения эффективности лечения патологии плаценты, тромбофилических состояний, других осложнений беременности. ...
2024 / Загородникова Ксения Александровна, Беттихер Офелия Андреевна, Зазерская Ирина ЕвгеньевнаВАК -
ПРИМЕНЕНИЕ ПЕРЕДОВЫХ ТЕХНОЛОГИЙ В ЛЕЧЕБНОЙ ФИЗИЧЕСКОЙ КУЛЬТУРЕ: ПЕРСПЕКТИВЫ И ДОСТИЖЕНИЯ
В контексте данной статьи рассмотрены новейшие методы лечебной физической культуры, которые открывают новые возможности для восстановления двигательных функций и улучшения качества жизни. Нами описаны ключевые направления использования новых технологий, включая искусственный интеллект, виртуальную...
2024 / Аляев Дмитрий Юрьевич, Кокарева Анастасия Александровна, Травина Дарья Николаевна -
Effects of Coconut Flour and Milk Powder Supplementation on the Physicochemical Properties of Peanut Butter
Peanut butter is a popular, versatile food spread globally known for its nutritional value and unique flavor. As consumer preferences evolve, there is an increasing demand for fortified products. Coconut flour and milk powder are potential fortification agents due to their nutritional benefits and...
2024 / Momin Khan, Suman Rana, Juwel Rana, Entaduzzaman Jony, Shoaib Arifin, Fahad Jubayer, Abdul AlimВАКAGRIS -
Терапевтический потенциал мезенхимных стволовых клеток и выделенных из них внеклеточных везикул при туберкулезе различных локализаций
Экспериментальные и клинические исследования с применением клеточной терапии, в которой мезенхимные стволовые клетки (МСК) и их производные – внеклеточные везикулы (ВВ) – применяют как один из компонентов лечения, пользуются большой популярностью. Действие МСК опосредовано выделением ВВ, которые...
2024 / Иванова Янина Георгиевна, Шумко Вероника Викторовна, Горелов Андрей Игоревич, Ремезова Анна Николаевна, Муравьев Александр НиколаевичВАК -
Интегральные взаимосвязи параметров соединительной ткани при реакции организма крыс на локальное облучение
Цель исследования. Установить гистологические изменения легкого и взаимосвязи этих изменений со свойствами наноразмерных частиц крови у лабораторных животных, вызванныех локальным облучением верхней части туловища рентгеновским излучением. Материалы и методы. Однократное локальное облучение крыс...
2024 / Надыров Э. А., Кравцова И. Л., Шклярова А. Н., Стародубцева М. Н. -
Visualizing Nucleic Acid Loci with the CRISPR-Cas System: Current Approaches
The visualization of genomic loci in living cells is crucial for detecting mutations and observing the spatial proximity of DNA regions in the 3D nuclear environment. One of the primary applications of the clustered regularly interspaced short palindromic repeats–CRISPR-associated protein 9...
2024 / Gerel A. Abushinova, Victoria V. Zherdeva, Ekaterina M. Vassina, Liliya G. Maloshenok -
Inhibition of Lung Cancer Stem Cell Migration and Growth Through Nano-Photodynamic Therapy
Recurrence and post-treatment spreading of lung cancer signify the existence of drug-resistant cancer stem cells (CSCs) that withstand current therapies. The development of metastases and secondary tumors is a primary contributor to mortality. CSCs play a pivotal role in driving cellular invasion...
2024 / Anine Crous, Heidi Abrahamse -
Silica Microspheres with Adsorbed Gold Nanostars for Single Cell SERS Detection of Formazan
In this study we report a rapid and sensitive surface-enhanced Raman spectroscopy (SERS)-based 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for in situ cell viability and proliferation assessment. The developed method based on silica microspheres with adsorbed gold...
2024 / Оlga А. Inozemtseva, Ekaterina S. Prikhozhdenko, Olga I. Gusliakova, Yulia A. Tyunina, Mariia S. Saveleva, Daniil N. Bratashov, Andrey M. Burov, Boris N. Khlebtsov -
Optical Properties of Fluorescent Tags Based on Gold Nanoparticles at Physiological Salt Content: In Vitro and In Vivo Study
The study describes the optical properties of fluorescent tags based on gold nanoparticles coated with a polymer shell with incorporated cyanine 5.5 in water and medium with a physiological salt background. The radiant efficiency was assessed by fluorescence tomography for the tag suspensions...
2024 / Andrei Demenshin, Maria Istomina, Elena Solovyeva
