CC BY
6DOI 10.24412/cl-37136-2023-1-154-154
THE SENSITIVE CYTOSENSOR BASED ON FIBER OPTIC LOCAL SURFACE PLASMONIC
RESONANCE
ZEWEI LUO*, YIXIANG DUAN*
Research Center of Analytical Instrumentation, School of Mechanical Engineering, Sichuan University,
Chengdu, Sichuan, PR China; Corresponding authors: [email protected], [email protected]
ABSTRACT
Fiber-optic-based localized surface plasmon resonance (FO-based LSPR) is a label-free analytical technique for directly analyzing cancer cells. FOs with different geometries have been reported to improve the sensitivity, including U-shaped1, 2 and Q-shaped fiber optic3-5. The Con A-modified U-shaped fiber optic enables a sensitive cytosensor for breast cancer cells. The limit of detectionof U-shaped fiber optic is 29-fold higher than that of the traditional straight one2. Further, an original Q-shaped FO (Q-FO) with high refractive index sensitivity was fabricated3. It was demonstrated that the enhanced binding area in Q-FO improves sensitivity for cancer cell detection4. Due to the advantages of simple operation, compactness, and ease in fabrication, Q-FO-based LSPR shows a promising application for cytosensor. Further, the induction of gold nanoparticles into gold nanorods for hybridized nanolayers enhances the electronic field and plasmonic photothermal effect6. Therefore, the Q-FO-based LSPR shows great potential for a new platform for diagnosis and treatment of cancer.
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