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17
AoSTcACT disease oriented
SOCIÉTÉ INTERNATIONALE D'ONCOLOGIE PÉHATRIQUE
SIOP ASIA CONGRESS
GERM CELL TUMOURS
ABSTRACT NO.: P-383
Characterization of germináis pediatric tumors in National Institute of Oncology and Radiobiology of Cuba (2000-2012)
Migdalia Perez, Mariuska Forteza, Jose Alert, Jesus Reno
National institute of Oncology and Radiobiology of Cuba, Havana
Key words: tumors, children, germ cells
Introduction. The tumors of germ cells in infancy constitute a heterogeneous group with diverse histology, represent of the 2 % the 5 % of the set of malignant diseases of infancy. The histological and genetics properties of these tumors vary according to the place of the primary tumor, the kind and the age of the patient. His clinical and histological characteristics differ significantly from the ones that predominate in adult age with a range of survival to 5 years in the teens of 15 to 19 years of 90 % at localized and of 60 % in patients with advanced tumors, if they are driven with surgery and Chemotherapy adyuvante developed in the last ones two decennia, which has been able to control these tumors in very aggressive occasions, with tall potential of metastización. ^ Aim. Describing the clinics characteristic, histology, treatment received in studied patients and estimating functions of global survival, free survival of progression and the influence
3 of some variables in the same.
O Materials and methods. In Pediatríc Service of Oncology and Radiobiology National Institute of Cuba, Himself I accomplish a retrospective study from January 1 the 2000
3 to December 31 , 2013 ,of patients with diagnosis of germinal tumors the, total of patients sign got constituted for 16 patients .
^ For the execution of investigation they checked the clinical histories of all of the patients included in the study. A data base in SPSS elaborated 12 itself. The variables analyzed
¡j¡ intervening the statistical method of Kaplan Meier themselves and results were exposed in draw and graphics.
U Results. This entity's prevalence was bigger in the female sex with a 69 %. The 46 % ofthe patients were on theage bracket of6to 10 years followed by the 39 % of16to 20 years.
S The incidence in our study was superior in patients of 6 to 10 years (46 %).
mi Generally they show the tumors of germ cells like indolent masses. 50 % of our patients I present pain like initial symptom and the bigger their number corresponded to the female
^ sex,the43 %showed up withtumor like initial sign, and the biggerpercent went fromthe masculinesextheir,I grasped lenderofsecuritiesinthe revised bibliography. Morefrequent
histology's were the SenoEndodermis'stumorinthefirstplace46%,followed oftheTeratoma Inmaturewith23 %.The 75 % was located at ovary in ourcases and theirmorefrequent histology was the Teratoma Inmature.
Conclusion. With present-day regimens of poly-chemotherapy correlated to surgery and at times we have achieved bigger number of complete remissions lifting the índices of survival of our patients.
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