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ПАТОФИЗИОЛОГИЯ ВИСЦЕРАЛЬНОЙ ЖИРОВОЙ ТКАНИ: АКЦЕНТ НА ЭПИКАРДИАЛЬНОМ ЖИРОВОМ ДЕПО
И.В. Тарасова
Центральный клинический госпиталь федеральной таможенной службы России, .ул. Открытое шоссе, 32, Москва, Российская Федерация 107143.
Автор, ответствен цй аа переписку: Тарасова И.В., ул. Открытое шоссе, 32, Москва, Российская Федерация, .107.143, кв-1аг76фуа.ги.
Для цкпфовмш Тарасова И.В. Патофизиология висцеральной жировой ткани: акцент на эликардиальнам жировом депо Н Иннммщионное развитие врача. 2024. С.7-14. (1оС 10.2441 2/СИ7091-2024-1-7-14
Поступила в редакцию: 21.11.2023: поступила после доработки: 12.01.2024; цяемга к печати: 25.В1.2024
PATHOPHYSIOLOGY OF VISCERAL ADIPOSE TISSUE: FOCUS OH EPICARDIAL FAT
Central Clinical HntyÜHl of the Federal СинЬзтв Service nF Russia, 32 Otk/ytie SiXiaae atr., Ktoficow, Ruaaian Federation, 1Q7143.
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Гетерогенность жировой ткани и причины патогенности висцерального ожирения
нальные особенности. Выделяют подкожный и висцеральный отделы жировой ткани, которые значительно отличаются по строен»«, функции и степени влияния не кэрдиометаболические риски М. Увеличение подкожного жира на свяаано с раавитием сердечно-сосудистых
окружает внутренние • . заболеваниями.
Кроме распределения на подкожный | висцеральный компоненты, жировая ткан, делится Н1 белую, буру», бежевую, желтую и розовую I
фуиодий 13]. В модуля
участие белые, бурые
□коло 80* всей жировой тк
электрической гетерогенное™ миокарда предсердий.
Профибротическое действие эпикардиальной жировой ткани при ожирении
субстрата Фа ЭЖТ >
Список литературы
1 Вертаин А.Л-, Сименюра С.С-, Кулаков В.В- Онофаниа: как оно ест И Амбулаторный прием. 2015. T.IWIC 3.1-Д1
2. Ibrahim W.W. Subcutaneous and visceral adipose tissue: structural end functional differences II Obes Rev.
2010. Vol. u №t P. 1.1.-1& dot 10,1111/
J.1467-7fl9X_2009.00623.x
3. Романова TM. Жировая ткань: цвета, депо и фуиодии И Ожиреше и метаболизм. 2021. Т. .18, №3.
.1.1
C. 282-301 dot 10.14341/ometl 2748
4. Bielczyk-Maczynska E. White Adipocyte Plasticity in Physiology aid Disease // Cells. 2019. VOL 8, №12. P, .1507. dot 10J390/cells8121507
5. Schcja L, Heeren J. The Endocrine function of adipose tissues ft health and cardlometabollc disease // Nat Rev Endocrinol 2019, Vol .15, »9. P. .507-524 dob 10.1038/s41574- 019-023 0 -6
6. Becher T., Palanisamy S., Kramer DJ., at aL Brown adipose tissue Is associated with cardlometabollc health II Nat Med. 2021 »27. P. 5S-6S. doli .1.0.1.03«/ B41591-02Q-.1.128.-7
7. Pollard A.E., Carting D. Thermogenic adipocytes: lineage, function and therapeutic potential II Blochem J.
2021 Vol. 477, »1t P. 207.1-2093. riot .10.1042/
BCJ2020029B
8. Doukbl E., Soghomonlan A., Sangenfcs C, at aL Browning Eplcardlal Adipose Tissue: Friend or Foe? II Cells. 2022. VoL .1.1, №B. P. 991 dot .103380/ ceUs11060991
9. Dozlo Eh Vlanello E., Brigand S, at aL Increased reectjve oxygen species production In eplcardlal adipose tissues from coronary artery disease patients Is associated with Brown-to-white adipocyte traris-dtffererrtiation // Int J Cardiol. 2014. Vol .174, №2. P. .4.13-41.4. dot 10.l01Bfl4cartL2014.04.045
,10. Chalt A., <ien Hartlgh LJ. Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Irriudrig Diabetes and Cardiovascular Disease // Front Cardlovasc Mad. 202a № 7. P. 22. dal! 10.3389/ fcvm.2020.0K>22
.11 Coats B.R., SchoenfeK K.Q, Barbosa-I orenzl V.C, et aL MatahoHcally Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Dtat-Irduced Obesity II Cell Rep. 20.17. VoL 20, NW3L P. 3.149-3.161 dot 10.1016fl.celrepj017.0a.096 ,12. Bermiidaz v., Durin P„ Rojas E^ et aL .The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstab With the Myocardium // Front Endocrinol (Lausanne). 2021 »12. P. 735070. dot 10.3389/ fendo.2021.735070
.13. Krishnan A., Sharma R, Yuan a, et eL The Role nf Eplcardlal Adipose Tissue In the Development of Atrial Fibrillation, Coronary Artery Disease and .Chronic Heart FalUre In the Context of Obesity and Type 2 Diabetes Mallltus: A Narrative Review // J Cardlovasc Dsv Dls. 2022. VoL 9, №7. P. 217, dot 10.339Dflcd<1907.0217 14. Gawatto M., Saljlc A., LI N., 8t ai. Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical slgnlflcanca II Cardlovasc Ras. 2023. VoL .1.18, »3. P. «4-630. dot 10.1083/evr/cvac093 ,15. Antonopoulos A.S., Margaritis M., Coutlnho P., et »L Adlponectln as a link between type 2 diabetes and vascUar NADPH oxidase activity In the human arterial wait the regulatory role of perivascular adipose tissue II Diabetes. 2015. VoL 64, N»8. P. 2207.-2219. dot 102337/ dbl4-imi
18. lacobelte G., wllens RJ. Echocardiography epicardial fat: a review of research and clinical applications // J Am Soc Echocardlogr. 2009. VOL 22, »12. P.
1311-1318; quiz .1417-1418. dot iai016/i.ccho^008.10^13 .17. Учасона EJ., Груздева ОБ, Дылава ЮА, и др.
роль в развитии сердечно-сосудистых заболеваний II Бюллетень сибирской медицины. 2018. Т. .17. № 4. С. 254-263. dot 10.20538Я682-0363-20.18-4-25.4-263 .18. Тегайвпо M.Q., Pandazzl С., Muscoglurt et eL Eplcardlal Adipose Tissue: A Novel Potential Imaging Marker of Comorbidities Caused by Chronic Inflammation II Nutrients. 2022 VOL 14, »14, P. 2926. dot 10.3330/ nu14.142828
.19. Mazurak T, Zhang L, Zalewsla" A, et aL Human eplcardlal adipose tissue Is a source of Inflammatory mediators II Clrctfatlon. 20.03. VOL .108, »20, P. 2480-2480. dot .10Л18.1ДО1СШ)000099542.573.13.С5 20. Hlrata Y, Tabata M, Kixobe R at aL Coronary
polarization In epicardial adipose tissue // J Am Coll CardloL 2011 VoL 58, »3. P. 248-255. dot .111016/ Цасс.2011.01.048
21 Чумакова FA, Веселовская RT., Гриценко .OA, и др. Зпикардиальное оаифение как фактор риска развития коронарного атеросклероза II Кардиология. 2013, Т. 53, № 1 С. 51-55.
22. Eroglu S. How do .we measure eplcardlal adipose tissue thickness by transthoracic echocardiography? // Anatol J CardloL 2015. VoL15, »5. P. .416-419. dot 1051S2/akii20l5388l
23. AntonopoiJos A_S_, Sanna F., Sabharwal N., et aL Detecting human coronary Inflammation by Imaging perivascular fat II Scl Transl Med. 20.17. VoL 8, »388. P. eaal285B. dot 10.1128/scitranalmecLaal2esa
24. Olkonomou EX, Marwan M., Desal M.Y, at aL Noninvasive detection of coronary Inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP C.T study): a post-hoc analysis of protective outcome data II Lancet 20.18. VoL 392, »1015.1 P. 929-939. dot .10.1018/ 50140-6736(18)31114-0
25. Oalbazzl N.. Martnr с, BenattJ О, at aL Atrial Fibrillation and Perl-Atrlal Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography // Diagnostics (Basel). 2021 Vol .1.1, »11 P. 2087. dot 10.3380/dlagnostics11112087
28. Cheng V.Y, Dey D, Tamarappoo R, et aL Pericardial fat burden on ECG-gated noncontrast CT In asymptomatic patients who subsequently experience adverse cardiovascular events // JACC Cardiovasc Imaging. 2016. VoL 3, »4. P. 352-360. dot .10.10ie/J4cmg2009.12.0.13 27. Thanassoull8 O., Massaro J.M., Hoffmann IJ, at aL Prevalence, distribution, and risk factor correlates of high pericardial and ritrathoracic lat depots in the Framlngham heart study II Clrc Cardlovasc Imagfrrg. 20.10 VoL Э, »5. P. 558-566. dot 10.1161 /QRClMAGING.110.956706
28 Wong CX, Sun MT, Odutayo A. et at Associations ai Eplcardlal, Abdominal, and Overall Adiposity .With Atrial Fibrillation. Clrc ATThythm ElectrophysloL 2016. VoL9, »12. P. e00437B. dot I0.1.iei/C1RCEP.118004378.
29. Mazurek Т., IGOszek M, KObyiecka M, et aL Relation of proinflammatory activity of eptcanllal adipose tissue to
the occurrence of atrial fibrillation // Am J CardioL 2014. VOL .113, №9. P. .1506-1500. dot .10.10.18/ J.amJcanl.2014.02.005
30. Heemers P, Hemdl H, GiiedJ K, at al. Atrial flbitlatlon Is associated with the fihrotic remodelling of adipose tissue In the subepkardlum of human and aheap atria II Eur Haart J. 2017. .Vol.38, »1 P. 53.-6.1. dot 10.1.09.3/eurheartI/ ehv825.
31. Mahajan R., Lau D.H., Brooks A.G, at aL Atrial Fibrilla-
tion and Obesity: Reverse Remodeling of Atrial Substrate With Weight Reductlo // JACC Clin ElactrophysloL 2021 VOL 7, №5. P. 830-641. dot 10.1Dl6/MaCBp.2020,1t0.1S 32. Vertadef N.. Gugllelml V, Bates E, at al Human epioardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adlpo-flbraklnee II Eur Heart J. 2015. VOL 36, №13. P. 785-8051 dot 10.1083/ aurheartj/eht099
L Vertkln AL, Slmenjura SS, KUakov W. Ozhlranle: kak ono esL Ambulatomyj prism. 2015; .1.(1); 31-41 On Rust). 2. Ibrahim M. Subcutaneous and visceral ad^ose tissue: structural and functional differences. Obes Rev. 2010; .1.1.(11:11-18. doiil0.1.1.11/J,1.4.67.-789X^0.08J.0.623ji
2021; 18(3); 282-3.0.1
harma H, Yuan D, at aL The Role of Adipose Tissue in the Development of Atrial % Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Typo 2 Dictates Mallitua: A Narrative Review. J Caretovasc Dev Dis. 2022; 917): 217, dot 10-3390flcdd9070217
sn J, "the endocrine function of adipose
Emlocrlnot. 20.19; .1519); 507-524. dot .10,1038/ S41574-.0.18-.0230-6
RBecher T, Palanbamy S, Kramer DJ, et aL Brown
adipose tissue Is associated with cardlometaboDc health. Nat Med. 2021; 27: .58.-65. dol! httpsrf/doLorg/10,1038/ s41591-.020-.1126.-7
7. Pollard AE, Carting D. Thermogenic adipocytes: lineage,
113(3):
Margerttis M, Coutlrtio P, at sL
vascular NADPH oxidase activity In the human arterial wall: the reguletory role of perivascular adipose tissue. Diabetes. 20.1S; 84(8): 2207-2219. doi: 102337/ db1.4-.1011
IS HJ.
«: 22(12): 1311-1319; quiz .1417-1418. dob 10.10iefl.8ChoJ009.1Q.013. 17. Uchasova EG, Gruzdeva OV, DyleraY.uA, at aL
Cardrai 2014; 174(2); .4.13.-414. doi: .10.10.18/ J.IJcard .2014,04.045
Nutrtsnta. 2022; .14.(1.4); 2926. floMOJ390/nul4142926 19. Mazurek T, Zhang L, Zalewakl A, et aL F
mediators. CirciAelion. 2003; .108(20): 2480-248& dot
10.1161/01.C1R.0000099542.57313.C 5
20. Hlrata Y, Tabata M, Kiroba H, at aL Coronary
al Functions during Diet-Induced Obesity. CbH Rap, 20.17; 20.(13); 3148-3161. doWO.1018/j.celrop .2017.08.090
.12. Barmiidez V, Durin P, Rojas E, at aL The Sick Adipose
fando.2021735070
2015; 15(5): .41.6.-419, d
23. Antonopoulos AS, Same F, Sabherwel N, et aL Dstactfrig human coronary Inflammation by Imaging perivascular fat Sci Transt Med. 2017; 8(398); eaal2658. dot 1 Q.11?6/scitranslmed.BBl?858
24. Oikonomau EK, Warwan M, Desai MY, el at Non-InvasIvB datactlon of coronary Inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT iludy): a post-hoc analysis of prospective outcome data. Lancet 2018; 392(10151).: 829-839. dot 10.1018/ S0140-6738t18)31114-0
25. GalbazzI N, Martini C, BenatH G at aL Atrial Fibrillation and Parl-Atrlal Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed .Tomography. Diagnostics fflasey. 2021; 11(1.1); 2087. dot 10.3390/ dlsgnostlc8l1112087
28. Cheng VY, Day D, Tamarappoo B, at aL Perlcardlel fet burden on ECG-gated noncontrast ,CT in asymptomatic patients who subsequently experience adverse cardiovascular events. JACC Cardtovasc (masiifl. 2010; 3.(4); 352-380. dot Iai0t6/ycmgj008-12.013 27. Thanassoulls G, Massaro JM, Hoffmann L), at aL Prevalence, distribution, end risk factor correlates of high perfcafdlal and Intrathoracic fat depots In the Framfrigham
heart study. Cte Cardfavasc (maflinfl. 2010; 3(5); 559-566. dot 10.1161 /CIRCIMAGING.110.956706
28. Wong CX, Sun MT, Odutayo A. at aL Associations of EplcardleL Abdominal, and Overall Adiposity With Atrial Fibrillation. Ore Airhylhm EleetrophyshL 2018; 8(12); B00437B. dot 10.1161/C1RCEP.116.004378.
29. Mezurek T, Klllszek M Kobylecka M, et aL Relation of profrrflBmmatory activity of epicardial adfcose tissue to the occurrence of atrial flbrllailon. Am J CardtoL 2014; .1.13(9): 1505-1508. doli 10.10.1B/Lamjcard .2014,02.005
30. Haemers P, Hwndl H, GuedJ K, at aL Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue In the subeplcardlum of hi»nan and sheep atria Eur Haart J, 2017; 38(1); 53-61. dot 10.1083/eurhear1i/ehv625
31 Mahaian R, Lau DH, Brooks AG, et aL Atrial Fibrillation and Obesity: Reverse Remodelng of Atrial Substrate With Weight Reduction. JACC CHn Elactrophyslol 2021; 7.(5): 630-641 dot 10.10l6/UacepJ2020.1.lQ15 32. Vertteclef N, Guglielmi V, Balse E, at aL Human aplcerdlal adipose tissue Induces fibrosis of tha atrial myocardium through the secretion of adfeo-flbroHnes. Eur Heart 1 2015; 36(13): 795-805a. doi: 10.1093/aurtteart}/ eht099
