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ЛЕЧЕБНЫЕ СРЕДСТВА ДЛЯ ОЧИСТКИ МОЧЕПОЛОВОГО
ТРАКТА НА РАСТИТЕЛЬНОЙ ОСНОВЕ 1 2 Велиев П.М. , Хусейнова А.Б. Email: [email protected]
1Велиев Первиз Мустафа оглы - кандидат медицинских наук, полковник, начальник отдела, отдел организации лечения и профилактики, Медицинский Центр при Министерстве чрезвычайных ситуаций Азербайджана; 2Хусейнова Айнура Бахадур гызы - кандидат фармацевтических наук, ассистент, кафедра фармацевтической технологии и организации фармации, Азербайджанский медицинский университет. г. Баку, Азербайджанская Республика
Аннотация: в настоящее время все большую актуальность приобретает проблема лечения мочекислого уролитиаза, которая возникает в связи нарушением обмена веществ в организме. Многими учеными мира разработано достаточное количество диуретиков, которые успешно используются в практике лечения как врачей-урологов, так и врачей других специальностей. С учетом вышесказанного на кафедре фармацевтической технологии и организации фармации Азербайджанского медицинского университета проводятся научные исследования, касательно разработки и создания лечебных средств на основе природного сырья Азербайджана, в том числе и средств для очистки мочеполового тракта. В научной статье впервые приводятся сведения по разработке натурального настоя шиповника, полученного из природных лекарственных растений флоры Азербайджана. Подробно изучено применение настоя шиповника при мочекислых уролетиазах у больных. Исследована, терапевтическая эффективность в составе комплексной терапии мочекислыхуролетиазов. Ключевые слова: МУ-мочекислый уролитиаз, мочевая кислота.
CLEANING OF AN URINOGENITAL TRACT BY HERBAL MEANS
12 Veliyev P-М. , Huseynova A-В.
1Veliyev Perviz Mustafa ogli - PhD in medicine, colonel, TREATMENT-PROPHYLAXIS DEALS DEPARTMENT OF THE MINISTRY OF EMERGENCY SITUATIONS OF THE REPUBLIC OF AZERBAIJAN; 2Huseynova Aynura Bahadur gizi - Doctor of Philosophy of Pharmaceutical Sciences, Assistant, PHARMACEUTICAL TECHNOLOGY AND PHARMACY ORGANIZATION DEPARTMENT, AZERBAIJAN MEDICAL UNIVERSITY, BAKU, REPUBLIC OF AZERBAIJAN
Abstract: аt present an increasing relevance is acquired by a problem of treatment of uroletiasis, which widespread refer to communication by a metabolic disorder in an organism. Many scientists of the world have developed enough number of diuretics which
are successfully being used in practice of treatment of both urologists, and other specialties. Taking into account the aforesaid at department of Pharmaceutical Technology and Pharmacy Organization of Azerbaijan Medical University scientific research, concerning development and creations of remedies on the basis of natural raw materials of the Republic of Azerbaijan including means for cleaning of an urinogenital tract is conducted. Data refer to development of a natural of natural infusion of the dogrose obtained from the herbs of flora of the Republic of Azerbaijan which provided firstly being described in the scientific article. Detaily being studied, administration of preparation of natural infusion of the dogrose form in case of uroletiasis. It is investigated, therapeutic efficiency as a part of complex therapy in case of uroletiasis. Keywords: uroletiasis, uric acid.
UDC 615.038
Abstract: Urulitiasis is a special group of problems of uric stones formation. The chemical structure of that uric stones depends upon particularly from purin metabolism disorders (stones from uric acid, xanthene, 2.8 - a degidroskiadenina (2.8DGA) and also salts of derivatives of uric acid-urats and cystins. The most common forms of that process is non-calsic origin of uric stone formation by other words uric uroletiasis (UU.).
About 10% of all uric stones get on a share of uric acid and sometimes is being defined as a concept which unites all uric stones consisting of formations of uric acid and its salts.
So, called urat stones that are the derivates of uric acid - by other words are urats. The noted stones seldom being met, but consisted no more than 0.5-1% of total number of uric stones (most of them are being widespread: urat ammonium, other urat origin are very rare).
The process of urat formation often being associated: with diarrhea, abuse of depletive, surgery resection of intestines and also with hypokalemia. Absolutely they can be formed only of stones of uric acid, related with alkaline replacements of pH urine.
Cistin formations of uric stones in adults by percentage formation are 0.3-1% (females -4% and males- 1%) of all stones, but that also accompanies by high ability of recurrence process. In pediatric practice the percent for these uric stones is 5-10% [10].
Urolithic disease - is a concept which means a metabolic disorder related with various endo- and exogenous reasons, in particular (hereditary features), which are characterized by existence of uric stones, as in kidneys, and in urogenital tract. It should be noted, and that the tendency to a recurrence is frequent and high.
As special factors of litogenez: concentration in quantity of urine the litogenic ions, existence of deficiency of inhibitors of crystallization and aggregation of crystals and also presence in urine an activators of stone formation, local disorders in kidneys [9].
As a purpose our investigation is efficiency identification of pharmaceutical activity of herbal means of tincture infusion of a dogrose and licorice root in case of urulitiasis.
Materials and methods of investigation.
As object of our research had been a dogrose and licorice root tincture being elaborated by us by a technique of two-phase extraction by water and 60% ethyl alcohol.
As an object of research had been 11 patients with mild case of urolitiasis.
Previously all investigated patients were being divided into 2 groups.
Table 1. Distribution of investigated patients in groups
Investigated patients with Group of patients
uroletiasis control main
Patients without complications 3 4
Patients with complications 2 2
Total 5 6
Note: p<0,05.
All investigated patients were aged from 20 up to 45 years. The research process of investigated patients was consisted of: collecting the anamnesis, clinical examination, carrying out laboratory and blood tool methods, of urine, and X-ray control of urogenital tract.
It was offered by us dogrose and licorice tincture infusion, for cleaning of a urogenital tract from crystals, as symptomatic diuretic therapy, for patients suffers by urulitiasis of mild clinical severity.
Preparation of a dogrose and licorice root tincture infusion was administrated in a dosage of 50 ml 1-2 times per day during 10-15 day courses of treatment for investigated patient of main group. Patients as the main group, as well as the patients of control group also accepted in a complex: vitamin therapy, anesthetics, spasmolytic and so on.
In serum of blood studied the content of urea of creatinine, uric acid of phosphates and pH were investigated.
Biochemical analyses of daily urine: uric acid, urea, oxalates determined by Jaffe's method in kinetic option.
Researches of indicators as the main, and control group of patients were being conducted. Statistical data processing was carried out with use of criteria of Student. (Calculated average size - X, an average quadratic deviation - and and an error of average size - t. For determination of the statistical importance of distinctions t-Student's criterion was being calculated).
The results of investigation: The clinical examination was being carried out by us.
Table 2. Dynamics of findings of urine being investigated patients suffer by urolitiasis in case of acceptation of a dogrose and licorice root by per os in complex therapy
Findings Main group Control group
urea 2,25±2,31 2,90±0,70
creatinin 0,12±0,11 0,07±0,01
phosphate 0,80±0,34 0,74±0,16
Uric acid 0,28±0,15 0,21±0,04
Daily urine - -
Uric acid 4,94±2,00 2,14±0,60
urea 630,04±77,78 342,72±70,13
oxalate 09,37±1,10 10.31±1,77
pH 6,09±0,65 6,49±0,9
Note: р <0,01.
Blood test. Blood test of investigated patients was being carried out both in the main group and control group of patients. No pathological findings were observed. Only non-considerable elevated SOE.
Clinical findings: Patients with uroletiasis had discomfort related with the process of urination, especially at the beginning of urination, swelling was noted, and increase of arterial blood pressure was noted in several investigated patients.
It should be noted that during acceptation of preparation in 1-2 patients' attacks of renal colic was observed. Colic was related with existence of a uric stone in a kidney approximately 2-3 sm. Patients confirmed that in anamnesis there were attacks earlier. In that case, renal colic was stopped by intravenous administration of baralgin solution-10.0ml.
We should note that in case of acceptation of that preparation patients had an obvious diuretic effect which was shown by frequent process of urination. During the process of urination the stones of small sizes were noted by patients. As one of clinical effects being noted easy laxative which was observed in several patients.
Thus, it is possible to recommend successfully usage of tincture infusion of a dogrose and licorice root in complex treatment for patients with mild cases of uroletiasis.
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